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Vandenbulcke K., Horvat L. I., De Mil M., Slegers G., Beele H. (2006)

Evaluation of the antibacterial activity and toxicity of 2 new hydrogels: a pilot study.
Int J Low Extrem Wounds 5: 109-114.

The aim of this study was to compare the antibacterial activities and toxicity profiles of 2 new hydrogel formulations with other products commonly used in the preparation of the wound bed. In conclusion, the results of this pilot study demonstrate that Flaminal and Flaminal Hydro exert antibacterial activity in vitro and in vivo, and using the MTT test in cultured keratinocytes, toxicity was not observed.

The antimicrobial activities of Flaminal and Flaminal Hydro were tested in vitro, using such pure cultures as Escherichia coli (ATCC10536), Pseudomonas aeruginosa (ATCC10145), Proteus vulgaris (ATCC 33420), Staphylococcus aureus (ATCC25923), and Candida albicans (ATCC10231).
Flaminal and Flaminal Hydro were found to be fully active against all microorganisms tested, irrespective of the incubation temperature. After incubation with the antimicrobial agent, silver sulfadiazine (Flammazine), no colony growth was observed. The plate overlaid by DuoDERM hydrogel did not show any effects of the gel on microbial population, and confluent growth of the bacteria and yeasts was observed.

In a clinical pilot study, we studied the in vivo antimicrobial activity on 7 chronic wounds on 4 patients. We evaluated, in vivo, the antimicrobial properties of Flaminal or Flaminal Hydro. Eight days after the start of the treatment with Flaminal or Flaminal Hydro, wounds had become negative for several bacterial species and C albicans. In the case of S aureus and S epidermidis, the eradicating effect of Flaminal and Flaminal Hydro was not complete.

In Vitro Toxicity The results of the MTT test of keratinocytes cultured with Flaminal Forte and Flaminal Hydro were comparable to the control samples, suggesting the absence of cytotoxic effects.

http://journals.sagepub.com/doi/abs/10.1177/1534734606289507

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